Percutaneous absorption type plaster

ABSTRACT

A transdermal patch comprising a backing  2  and an adhesive layer  3  laminated on the backing  2 , wherein the adhesive layer  3  comprises a rosin-based resin and petroleum resin as a tackifier, the total compounding amount of the rosin-based resin and the petroleum resin is in a range of 15% by mass to 50% by mass, and compounding amount of the petroleum resin is ⅓ times by mass to 4 times by mass as that of the rosin-based resin.

TECHNICAL FIELD

This invention relates to a transdermal patch comprising a backing andan adhesive layer laminated thereon.

BACKGROUND ART

Concerning an anti-inflammatory agent such as ketoprofen, in order to beabsorbed through the skin, many kinds of transdermal patch are known,and a patch using an adhesive base agent including a thermoplasticelastomer such as natural rubber, acrylate polymers, andstyrene-isoprene-styrene blocka copolymers is known. In Japanese PatentNo. 2816765, for example, a patch having an adhesive layer consisting ofstyrene-isoprene-styrene block copolymer as an adhesive base agent (basepolymer), a rosin ester derivative as a tackifier, L-menthol as asolubilizer, liquid paraffin as a plasticizer, and an anti-inflammatoryagent such as ketoprofen.

However, for conventional anti-inflammatory analgesic patch described inJapanese Patent No. 2816765, in order to provide a temporal stability inits sufficient adhesibility, increase of a compounding amount of rosinester derivatives is required. However, this increase brings about aproblem such that releasability of a medicine is reduced. The problem isprominent when a medicine such as diclofenac or a salt thereof which hasgenerally difficulty in satisfying both of solubility and releasabilityis used as the medicine.

DISCLOSURE OF INVENTION

The present invention was achieved in consideration of the problemsincluded in the conventional technique, and the object of the inventionis to provide a transdermal patch that, even in the case where amedicine such as diclofenac or a salt thereof which generally hasdifficulty in satisfying both of sufficient solubility and releasabilityis used as the medicine, both of sufficient solubility and releasabilityof the medicine are achieved in a high degree with a good balance, andthat the temporal stability thereof in adhesive force is also superior.

The present inventors made efforts to achieve the aforementioned object,and found that the object is achieved by incorporating a rosin-basedresin and a petroleum resin at a prescribed compounding ratio as atackifier in the adhesive layer, to reach the invention.

In other words, the transdermal patch of the invention is characterizedin being a transdermal patch having a backing and an adhesive layerlaminated on the backing, wherein the adhesive layer comprises arosin-based resin and petroleum resin as a tackifier, the totalcompounding amount of the rosin-based resin and the petroleum resin isin a range of 15% by mass to 50% by mass, and the compounding amount ofthe petroleum resin is ⅓ times by mass to 4 times by mass as that of therosin-based resin.

It is preferable for the transdermal patch of the invention that therosin-based resin is a hydrogenated rosin ester, and that the petroleumresin is an alicyclic petroleum resin or a hydrogenated alicyclicpetroleum resin.

Preferably, the transdermal patch of the invention comprises one or moreselected from the group consisting of diclofenac and a pharmaceuticallyacceptable salt thereof in the adhesive layer as a medicine.

Moreover, preferably the transdermal patch of the invention furthercomprises L-menthol and/or polyethylene glycol in the adhesive layer.Regarding such polyethylene glycol, a polyethylene glycol having anaverage molecular weight in a range from 200 to 20,000 is morepreferable.

BRIEF DESCRIPTION OF DRAWINGS

FIG. 1 is a schematic cross-sectional view showing a preferableembodiment of the transdermal patch of the invention.

FIG. 2 is a graph exhibiting the results of medicine releasability testsin Examples 1, 4 and 5 and Comparative Examples 1 and 4.

FIG. 3 is a graph exhibiting the results of medicine releasability testsin Examples 1, 10 and 11.

BEST MODE FOR CARRYING OUT THE INVENTION

FIG. 1 is a schematic cross-sectional view showing a preferableembodiment of the transdermal patch of the invention. The transdermalpatch 1 of the invention is a transdermal patch comprising a backing 2and an adhesive layer (pressure-sensitive adhesive layer) 3 laminated onthe backing 2, which may be further laminated with a release film 4 thatis peeled off when used. In addition, the adhesive layer 3 comprises arosin-based resin and a petroleum resin as a tackifier.

First, the adhesive layer of the transdermal patch according to theinvention will be explained. The adhesive layer according to theinvention comprises an adhesive base agent and a tackifier and, ifnecessary, a medicine. Examples of the adhesive base agent according tothe invention include styrene-isoprene-styrene block copolymer,styrene-butadiene-styrene block copolymer, styrene-isoprene rubber,styrene-butadiene rubber, polyisoprene, polyisobutylene, polybutadienerubber, silicone rubber, acrylate polymer (a copolymer of at least twospecies of butyl acrylate, 2-ethylhexyl acrylate, vinyl acetate,methacrylate, hydroxyethyl acrylate, glycidyl methacrylate, methoxyethylacrylate and acrylic acid), natural rubber and polyurethane-basedrubbers. Among them, from the viewpoint of cohesive property, weatherresistance, aging resistance or chemical resistance,styrene-isoprene-styrene block copolymer and polyisobutylene arepreferable, and a mixture of styrene-isoprene-styrene block copolymerand polyisobutylene is especially preferable.

Examples of such styrene-isoprene-styrene block copolymer includeCaliflex TR-1107, TR-1111, TR-1112, TR-1117 (trade name, ShellChemicals), Quintac 3530, 3421, 3570C (trade name, ZEON CORPORATION),JSR SIS-5000, 5002 (trade name, Japan Synthetic Rubber Co., Ltd.),Kraton D-KX401CS, D-1107CU (trade name, Shell Chemicals), Solprene 428(trade name, Phillips Petroleum), which may be used individually or incombination of two or more of them. The compounding amount of thestyrene-isoprene-styrene block copolymer is preferably 5-40% by mass ofthe whole amount of the adhesive layer (adhesive formulation), morepreferably 10-35% by mass. The compounding amount lower than the lowestlimit described above tends to reduce the cohesive property or shapepreservation property of the base agent and, on the other hand, thecompounding amount higher than the highest limit described above tendsto increase cohesive power of the base agent to reduce easilyadhesibility, processability or the like.

Examples of polyisobutylene include Oppanol B-3, B-10, B-15, B-50,B-100, B-200 (trade name, BASF Ltd.), Vistanex LM-MS, LM-MH, MML-80,LLM-100, LLM-120, LLM-140 (trade name, Exxon Chemical Company) andTetrax 3T, 4T, 5T, 6T (trade name, NIPPON PETROCHEMICALS COMPANY,LIMITED), which may be used individually or in combination of two ormore of them. The compounding amount of the polyisobutylene ispreferably 1-25% by mass of the whole amount of the adhesive layer(adhesive formulation), more preferably 2-20% by mass. The compoundingamount lower than the lowest limit described above tends to reduceadhesibility of the base agent and, on the other hand, the compoundingamount higher than the highest limit described above tends to reduce theshape preservation property of the base agent during long preservation.

The adhesive layer according to the invention comprises a rosin-basedresin and a petroleum resin as a tackifier along with the adhesive baseagent described above. Examples of the rosin-based resin include naturalresin rosin, denatured rosin, rosin esters (such as rosin glycerin esterand rosin pentaerythritol ester), hydrogenated rosin esters (such ashydrogenated rosin glycerin ester and hydrogenated rosin pentaerythritolester). Among them, from the viewpoint of skin irritation and agingresistance, hydrogenated rosin ester is preferable, and hydrogenatedrosin glycerin ester is especially preferable. Specifically, examples ofsuch rosin-based resin include Ester gum H (trade name, ARAKAWA CHEMICALINDUSTRIES LTD.), Pinecrystal KE-100, KE-311 (trade name, ARAKAWACHEMICAL INDUSTRIES LTD.), Foral 85, 105 (trade name, RIKA-HerculesInc.) and Stebelite Ester 7, 10 (trade name, RIKA-Hercules Inc.), whichcan be used individually or in combination of two or more of them.

Examples of the petroleum resin include CS synthesized petroleum resins(copolymers of at least two of isoprene, cyclopentadiene, 1,3-pentadieneand 1-pentene; copolymers of at least two of 2-pentene anddicyclopentadiene; resins mainly composed of 1,3-pentadiene, and thelike), C9 synthesized petroleum resins (copolymers of at least two ofindene, styrene, methylindene, α-methylstyrene, and the like),dicyclopentadiene-based synthesized petroleum resins (copolymer mainlycomposed of dicyclopentadiene with isoprene and/or with 1,3-pentadiene,and the like). C9 synthesized petroleum resins are preferable from theviewpoint of weather resistance and miscibility with the adhesive baseagent. Also, from the view point of another classification, thepetroleum resin includes alicyclic petroleum resins (alicyclichydrocarbon resins), hydrogenated alicyclic petroleum resins, aliphaticpetroleum resins (aliphatic hydrocarbon resins), hydrogenated aliphaticpetroleum resins, aromatic petroleum resins and the like. From theviewpoint of adhesive force, miscibility with an adhesive base agent andaging resistance, alicyclic petroleum resins and hydrogenated alicyclicpetroleum resins are preferable, and hydrogenated alicyclic petroleumresins are especially preferable. Specific examples of such petroleumresin include ARKON P-70, ARKON P-90, ARKON P-100, ARKON p-115, ARKONP-125 (trade name, ARAKAWA CHEMICAL INDUSTRIES LTD.), Escorez 8000(trade name, ESSO Petroleum Co., Ltd.), which may be used individuallyor in combination of two or more of them.

In the adhesive layer according to the invention, the total compoundingamount of the rosin-based resin and the petroleum resin is 15% by massto 50% by mass, preferably 20% by mass to 45% by mass. The totalcompounding amount lower than the lowest limit described above tends notto give sufficient adhesibility that makes a long-term attachingpossible and, on the other hand, that higher than the highest limitdescribed above tends to bring about decrease of medicine release, painat peeling, or generate easily skin rash. Further, in the adhesive layeraccording to the invention, the compounding amount of the petroleumresin is ⅓ times by mass to 4 times by mass as the compounding amount ofthe rosin-based resin, preferably ⅖ times by mass to 3 times by mass. Aratio lower than the lowest limit described above deterioratesreleasability of a medicine and generates reduction of the adhesiveforce over time due to penetration of an adhesive agent (applicator)into the backing during preservation because of a small cohesion forceof the resin. On the other hand, a ratio higher than the highest limitdescribed above deteriorates miscibility with a medicine to generatecrystallization of the medicine.

In this connection, the adhesive layer according to the invention mayfurther comprise another kind of tackifier (such as terpene-based resin,phenol-based resin and xylene-based resin) in addition to theaforementioned rosin-based resin and petroleum resin.

The adhesive layer according to the invention preferably comprises amedicine if necessary, in addition to the adhesive base agent andtackifier described above. The medicine applicable to the invention isnot limited insofar as it is a medicine absorbed transdermally, forexample, includes an anti-inflammatory agent, muscle relaxant, cardiacstimulant, therapeutic agent for circulatory organ and anti-allergyagent. Among them, an anti-inflammatory agent selected from the groupconsisting of salicylic acid, sulpyrine, amfenac, diclofenac,loxoprofen, tolmetin, lobenzarit, ketorolac, ketoprofen, ibuprofen,felbinac, flurbiprofen, indomethacin, zomerac, flufenamic acid,fenoprofen, bromfenac, hydrocortisone succinate, hydrocortisonephosphate, dexamethasone phosphate, dexamethasone m-sulfobenzoate,betamethasone phosphate, prednisolone succinate, prednisolone phosphate,methylprednisolone succinate, prasterone sulfate, ketotifen, oxybutynin,fentanyl, pergolide and a pharmaceutically acceptable salt thereof ispreferable. The transdermal patch of the invention allows to satisfyeasily both of solubility and releasability of the medicine, thus it isparticularly preferable to apply diclofenac or a pharmaceuticallyacceptable salt thereof, which was conventionally difficult insatisfying both of solubility and releasability.

Examples of a pharmaceutically acceptable salt of the medicine includealkali metal compounds, alkali earth metal compounds and ammoniumcompounds and, specifically, sodium, potassium, calcium, magnesium,ammonia, dimethylamine, diethylamine, trimethylamine, tetramethylammonium, monoethanolamine, diethanolamine and triethanolamine.

The compounding amount of the medicine in the adhesive layer accordingto the invention is not limited insofar as a pharmaceutical effect isexerted. Generally, it is 0.1-40% by mass, preferably 0.5-30% by mass.The medicine may be used individually or in combination of two or morekinds.

In the case where a compounding medicine is an acidic medicine such asdiclofenac or a pharmaceutically acceptable salt thereof, it ispreferable that the adhesive layer further comprises an adduct of basicsubstance. “An adduct of basic substance” refers to a compound of abasic substance added with another substance to form a salt. Preferably,the basic substance is Lewis base, and the other substance is asubstance having an electron deficient system such as Lewis acid or asubstance that can form an electron deficient system such as an organichalide. The adduct of a basic substance includes specifically salts ofammonium compounds, and preferably acid adducts of ammonia such asammonium chloride and acid adducts of amines such as diethylaminehydrochloride. When an adduct of a basic substance is added, itscationic moieties are ion-exchanged by or form complex ionic substanceswith a part or whole of the cationic moieties of an acidic medicine, andthe ion-exchanged body or complex ionic substance formed as the resulttends to improve a transdermal absorption property.

The compounding amount of the adduct of a basic substance in theadhesive layer according to the invention may be an amount sufficient toform an ion pair with an acidic medicine and, generally, preferablywithin a range of 0.5-10 times by mol the acidic medicine. The adduct ofa basic substance may be used individually or in combination of two ormore kinds.

In the patch of the invention, the adhesive layer may further comprisean organic acid. Examples of such organic acid include aliphatic (mono,di, tri) carboxylic acids (acetic acid, propionic acid, isobutyric acid,caproic acid, caprylic acid, lactic acid, maleic acid, pyruvic acid,oxalic acid, succinic acid, tartaric acid, and the like), aromaticcarboxylic acids (phthalic acid, salicylic acid, benzoic acid, acetylsalicylic acid, and the like), alkyl sulfonic acids (methane sulfonicacid, ethane sulfonic acid, propyl sulfonic acid, butane sulfonic acid,polyoxyethylenealkylether sulfonic acid, and the like), alkyl sulfonicacid derivatives (N-2-hydroxyethylpiperidine-N′-2-ethane sulfonic acid,and the like) and cholic acid derivatives (dehydrocholic acid, and thelike). Among them, monocarboxylic acids or alkyl sulfonic acids arepreferable, and especially, acetic acid is preferable. These organicacids may be used in the form of salts thereof or a mixture of theorganic acid and the salt thereof.

The organic acid and/or the salt thereof is arbitrarily compoundedpreferably in a range of 0.01-20% by mass, more preferably 0.1-15% bymass, and especially preferably 0.1-10% by mass based on the total massof the composition consisting of the adhesive layer in view of skinpermeability and skin irritating property of the medicine. Thecompounding amount lower than 0.01% by mass tends to make the skinpermeability of the medicine insufficient and, on the other hand, thecompounding amount higher than 20% by mass tends to generate easily skinirritation.

In the patch of the present invention, preferably the adhesive layerfurther comprises an absorption enhancer. As an absorption enhancer, anycompound conventionally recognized to have an absorption enhancingeffect at the skin may be used, including, for example,

-   (1) fatty acids, aliphatic alcohols, fatty acid amides, and fatty    acid ethers having 6 to 20 carbons, which may be saturated or    unsaturated, and also may be cyclic, linear, or branched;-   (2) aromatic organic acids, aromatic alcohols, and aromatic organic    acid esters or ethers; and-   (3) lactic acid esters, acetic acid esters, monoterpenes,    sesquiterpenes, Azone, Azone derivatives, glycerin fatty acid    esters, propylene glycol fatty acid esters, sorbitan fatty acid    esters (Span), polysorbates (Tween), polyethylene glycol fatty acid    esters, polyoxyethylene hydrogenated castor oils (HCO),    polyoxyethylene alkyl ethers, sucrose fatty acid esters and    vegetable oils.

Specifically, preferable examples include caprylic acid, capric acid,caproic acid, lauric acid, myristic acid, palmitic acid, stearic acid,isostearic acid, oleic acid, linoleic acid, linolenic acid, laurylalcohol, myristyl alcohol, oleyl alcohol, isostearyl alcohol, cetylalcohol, lauric acid diethanol amide, myristyl myristate, octyldodecylmyristate, cetyl palmitate, methyl salicylate, salicylic acid ethyleneglycol, cinnamic acid, methyl cinnamate, cresol, cethyl lactate, lauryllactate, ethyl acetate, propyl acetate, geraniol, thymol, eugenol,terpineol, L-menthol, borneol, d-limonene, isoeugenol, isoborneol,nerol, dl-camphor, glycerin monocaprirate, glycerin monocaprate,glycerin monolaurate, glycerin monooleate, sorbitan monolaurate, sucrosemonolaurate, polysorbate 20, propylene glycol monolaurate, polyethyleneglycol monolaurate, polyethylene glycol monostearate, polyoxyethyleneoleyl ether, polyoxyethylene lauryl ether, HCO-60, pirotiodecane andolive oil. Among them, oleic acid, lauryl alcohol, myristyl alcohol,oleyl alcohol, isostearyl alcohol, lauric acid diethanol amide,L-menthol, glycerin monocaprirate, glycerin monocaprate, glycerinmonooleate, sorbitan monolaurate, propylene glycol monolaurate,polyoxyethylene oleyl ether, polyoxyethylene lauryl ether andpirotiodecane are more preferable, and oleic acid, oleyl alcohol andL-menthol are particularly preferable. In the case where the compoundedmedicine is an acidic medicine such as diclofenac or a pharmaceuticallyacceptable salt thereof, the use of oleic acid, oleyl alcohol orL-menthol as the absorption enhancer tends to improve the skinpermeability of the medicine, and the use of L-menthol especially tendsto improve it.

Such absorption enhancer may be used in combination of two or morekinds, and the combination of oleic acid and L-menthol, or oleyl alcoholand L-menthol is especially preferable. These combinations tend toprominently improve the skin permeability of the medicine. Inconsideration of sufficient permeability as a patch and irritatingproperties to the skin such as reddening or edema, the absorptionpromoter is compounded suitably within a range of 0.01-20% by masspreferably, 0.05-10% by mass more preferably, and 0.1-5% by massespecially preferably based on the total mass of the compositionconsisting of the adhesive layer.

In the patch of the invention, preferably, the adhesive layer furthercomprises a solubilizer. Examples of such a solubilizer include liquidfatty acid esters (isopropyl myristate, hexyl laurate, diethyl sebacate,diisopropyl sebacate, and the like), diethylene glycol, triethyleneglycol, polyethylene glycol, propylene glycol, dipropylene glycol,triacetin, triethyl citrate and crotamiton. Among them, diethyleneglycol, triethylene glycol, polyethylene glycol, propylene glycol anddipropylene glycol are preferable. The use of these solubilizer tends toimprove solubility and skin permeability of the medicine, even when amedicine generally having difficulty in satisfying both of solubilityand releasability such as diclofenac or a salt thereof is used, and theuse of polyethylene glycol tends to especially improve those properties.

When polyethylene glycol is used as a solubilizer, the average molecularweight thereof is preferably 200-20,000, more preferably 400-6,000,especially preferably 1,000-6,000. Polyethylene glycol having theaverage molecular weight smaller than the smallest limit above describedtends to allow the polyethylene glycol and the medicine to react to forman ester pair, causing decrease of the content of the medicine withtime. Along with increase of the average molecular weight, the decreaseof the medicine content tends to be suppressed sufficiently.

Such solubilizer may be used in combination of two or more kinds. Thesolubilizer is compounded suitably in a range of 0.5-20% by masspreferably, 1-15% by mass more preferably, and 1-10% by mass especiallypreferably in total based on the whole composition composing theadhesive layer, while considering sufficient permeability andmaintenance of sufficient cohesion force as a patch.

In the patch of the invention, the adhesive layer may further comprise aplasticizer. Examples of such plasticizer include liquid paraffin,petroleum oils (paraffin process oils, naphthen process oils, aromaticprocess oils, and the like), squalane, squalene, vegetable oils (oliveoil, camellia oil, castor oil, tall oil, peanut oil, and the like),silicone oil, dibasic acid ester (dibutyl phthalate, dioctyl phthalate,and the like), liquid rubber (polybutene, liquid isoprene rubber, andthe like) and glycol salicylate. Among them, liquid paraffin and liquidpolybutene are especially preferable.

Such plasticizer may be used in combination of two or more kinds. Theplasticizer is compounded suitably in a range of 5-70% by masspreferably, 10-60% by mass more preferably, and 10-50% by massespecially preferably in total based on the whole composition consistingof the adhesive layer, while considering sufficient permeability andmaintenance of sufficient cohesion force as a patch.

In the patch of the invention, the adhesive layer may further comprisean antioxidant, filler, a crosslinker, a preservative, an ultravioletabsorbent or the like if necessary. Desirable examples of suchantioxidants include tocopherol and ester derivatives thereof, ascorbicacid, ascorbic acid stearic acid ester, nordihydroguaiaretic acid,dibutylhydroxytoluene (BHT) and butylhydroxyanisole. Desirable examplesof such filler include calcium carbonate, magnesium carbonate, silicate(e.g., aluminum silicate, magnesium silicate, and the like), silicicacid, barium sulfate, calcium sulfate, calcium zincate, zinc oxide andtitanium oxide. Desirable examples of such crosslinker includethermosetting resins such as amino resin, phenol resin, epoxy resin,alkyd resin and unsaturated polyester, isocyanate compounds, blockisocyanate compounds, organic crosslinker, and inorganic crosslinkersuch as metals and metal compounds. Desirable examples of suchpreservative include ethyl paraoxybenzoate, propyl paraoxybenzoate andbutyl paraoxybenzoate. Desirable examples of such ultraviolet absorbentinclude p-aminobenzoic acid derivatives, anthranilic acid derivatives,salicylic acid derivatives, coumarin derivatives, amino acid compounds,imidazoline derivatives, pyrimidine derivatives and dioxane derivatives.

Such antioxidants, filler, crosslinkers, preservatives, ultravioletabsorbents are compounded suitably in a range of 10% by mass or lesspreferably, 5% by mass or less more preferably, and 2% by mass or lessespecially preferably in total based on the total mass of thecomposition consisting of the adhesive layer of the patch.

Thickness of the adhesive layer according to the invention (excludingthicknesses of a backing and peelable liner described below), which isprepared by use of the components described above, is preferably 50-300μm, more preferably 80-200 μm. A thickness lower than 50 μm tends toreduce persistence of an adhesion or adherability and, on the otherhand, a thickness more than 300 μm tends to reduce cohesion force orshape preservation property.

As the backing of the transdermal patch of the invention, a backing thatdoes not influence release of the medicine is desirable and stretchableor unstretchable one may be used. Examples of backings usable for theinvention include a film, sheet, sheet-shaped porous material,sheet-shaped foam, woven or nonwoven material of synthetic resins suchas polyethylene, polypropylene, polybutadiene, ethylene-vinyl acetatecopolymer, polyvinylchloride, polyester, nylon and polyurethane, paper,and a laminate thereof.

Next, a preferable example of the production method of the transdermalpatch of the invention will be explained. First, respective components(excluding a medicine) consisting of the adhesive layer are mixed withheating at the predetermined ratio under an inactive atmosphere such asnitrogen, the medicine is added, and then the mixture is further stirredto give a homogeneous dissolved composition. Alternatively,aforementioned components and the medicine are added to an organicsolvent such as hexane, toluene or ethyl acetate so as to become thepredetermined ratio, which is stirred to give a homogeneous dissolvedcomposition.

Next, the dissolved composition is spread directly onto a backing by ausual method, which is covered by a peelable liner and then cut into adesired shape. Or, the dissolved composition may be spread once onto apeelable liner, which is then disposed on a backing to press andtransfer the dissolved composition to the backing followed by cuttinginto a desired shape. On the other hand, when the homogeneous dissolvedcomposition has been obtained by using an organic solvent, preferably itis spread onto a backing followed by drying with a drier to evaporateand remove the organic solvent, which is then covered with a peelableliner; or it is spread onto a peelable liner followed by drying with adrier to evaporate and remove the organic solvent, which is thensubjected to press and transfer to a backing.

Examples of such peelable liners include peelable paper, cellophane andsynthetic resin films (polyethylene, polypropylene, polyester,polyvinylchloride, polyvinylidene chloride, and the like) having beensubjected to a peeling treatment (a treatment for facilitating peeling;e.g., silicone treatment).

The order of compounding each of base components, the medicine and otherdoping components in the aforementioned production method is describedonly as an example, and the production method of the patch is notlimited to the method of the compounding order.

EXAMPLES

The invention will be explained further specifically on the basis ofExamples and Comparative Examples, however the invention is not limitedto these Examples and many changes may be possible within the scope ofthe technical idea of the invention.

Examples 1-9 and Comparative Examples 1-4

Components shown in Table 1 were mixed to toluene to form a mixture,which was stirred to give a homogenous dissolved composition. Next, thedissolved composition was spread onto a peelable liner (polyester film)so as to form a layer having a dried thickness of 100 μm followed byevaporating and removing the toluene with a drier. Then it was disposedon a backing (polyester cloth having a thickness of about 550 μm) topress and transfer the adhesive layer to the backing to give atransdermal patch.

Numerical values of the prescription represented in Table 1 mean “% bymass.” As the components listed in Table 1, followings were used.

-   SIS (styrene-isoprene-styrene block copolymer): manufactured by    Japan Synthetic Rubber Co., Ltd., trade name: SIS-5000-   PIB (polyisobutylene): manufactured by BASF, trade name: Oppanol    B-200-   Liquid paraffin: Kaneda Co., Ltd., trade name: Hi-Call M-352-   Hydrogenated rosin ester: manufactured by RIKA-Hercules Inc., trade    name: Foral 85-   Alicyclic petroleum resin: manufactured by ARAKAWA CHEMICAL    INDUSTRIES LTD., trade name: ARKON P-100-   Polyoxyethylene oleyl ether: manufactured by Nikko Chemicals Co.,    Ltd., trade name: NIKKOL BO-7

Polyethylene glycol: manufactured by Sanyo Chemical Industries, tradename: Macrogol 4000, average molecular weight: 2600-3800 TABLE 1 Comp.Comp. Comp. Comp. Ex. 1 Ex. 2 Ex. 3 Ex. 4 Ex. 5 Ex. 6 Ex. 7 Ex. 8 Ex. 9Ex. 1 Ex. 2 Ex. 3 Ex. 4 SIS 15 25 15 10 10 20 25 15 25 15 15 15 10 PIB10 5 5 15 10 15 15 5 10 5 5 10 liquid paraffin 36 46 41 41 46 36 16 5931 36 41 36 46 hydrogenated rosin 15 5 20 8 10 15 15 5 8 30 5 20 esteralicyclic petroleum 15 10 10 17 15 5 20 10 32 30 30 5 resin ammoniumchloride 1 1 1 1 1 1 1 1 diethylamine 1 1 1 1 1 hydrochloride oleylalcohol 3 3 3 3 oleic acid 3 3 3 3 polyoxyethylene oleyl 3 3 3 etherdipropylene glycol 2 2 2 2 triethylene glycol 2 2 polyethylene glycol 22 2 2 2 crotamiton 2 Diclofenac sodium 3 3 3 3 3 3 3 3 3 3 3 3 3

Examples 10-11

A transdermal patch was obtained similarly to Example 1 except thatcomponents shown in the following prescription were used. Numericalvalues in the prescription mean “% by mass.” Prescription of Example 10:SIS 15 PIB 10 Liquid paraffin 34 Hydrogenated rosin ester 15 Alicyclicpetroleum resin 15 Ammonium chloride 1 Oleyl alcohol 3 L-menthol 2Dipropylene glycol 2 Diclofenac sodium 3 Prescription of Example 11: SIS15 PIB 10 Liquid paraffin 34 Hydrogenated rosin ester 15 Alicyclicpetroleum resin 15 Ammonium chloride 1 Oleic acid 3 L-menthol 2Polyethylene glycol 2 Diclofenac sodium 3

Examples 12-17

Respective transdermal patches were obtained similarly to Example 2except that the followings were used as polyethylene glycol.

-   Example 12: manufactured by Sanyo Chemical Industries, trade name:    Macrogol 200, average molecular weight: 190-210-   Example 13: manufactured by Sanyo Chemical Industries, trade name:    Macrogol 400, average molecular weight: 380-420-   Example 14: manufactured by Sanyo Chemical Industries, trade name:    Macrogol 600, average molecular weight: 570-630-   Example 15: manufactured by Sanyo Chemical Industries, trade name:    Macrogol 1500, average molecular weight: 1300-1600-   Example 16: manufactured by Sanyo Chemical Industries, trade name:    Macrogol 4000, average molecular weight: 2600-3800-   Example 17: manufactured by Sanyo Chemical Industries, trade name:    Macrogol 6000, average molecular weight: 7300-9300

Test Example 1 Adhesive Property Test

Temporal stability of the adhesive force of the transdermal patchesobtained in Examples 15, 6 and 8 and Comparative Examples 1 and 4 areevaluated in the following way. Specifically, a patch, which had beenleft in a temperature-controlled room at 25° C. for 30 min or more inadvance, was cut to a size of a test piece holding ring and, after apeelable liner (liner) was peeled off, the adhesive layer was attachedto the test piece holding ring while setting its adhesive face downwardto place it on a test table. Next, a probe shaft was raised at aconstant rate to contact the adhesive face of the patch to a probe madeof bakelite having a diameter of 5 mm with a pressure loading of 100g/cm² for 1 second. Then, the probe shaft was moved downward again at arate of 0.5 cm/sec to separate off the probe from the adhesive face, andthe force (unit: g/cm²) required at that time was measured as anadhesive force. The measurements of the adhesive force described abovewere carried out for a patch just produced, and patches preserved for amonth at 40° C. or 50° C. to evaluate the stability of adhesive forcewith time. The results obtained are shown in Table 2. TABLE 2 Comp.Comp. Ex. 1 Ex. 5 Ex. 6 Ex. 8 Ex. 1 Ex. 1 just produced 110 105 95 80112 101 stored at 40° C. 107 108 93 79 87 86 for 1 month stored at 50°C. 100 103 85 82 44 55 for 1 month

As is evident from the results shown in Table 2, it was confirmed thatthe patch of the invention is excellent in the stability of the adhesiveforce with time and, on the other hand, patches comprising no or alittle amount of petroleum resin as a tackifier are poor in thestability of the adhesive force with time.

Test Example 2 Medicine Solubility Test

The medicine solubility (medicine crystallization) of the transdermalpatches obtained in Examples 2, 3, 7 and 9 and Comparative Examples 2and 3 were evaluated as follows. That is, the patches were preserved ina thermo-hygrostat of 25° C. and 60% for a month, and thencrystallization of the medicine in the adhesive layer was observed andevaluated according to the following criteria:

-   x crystal separation;-   Δ crystal was observed slightly;-   ∘ no crystal separation.

The obtained results are shown in Table 3. TABLE 3 crystallizationExample 2 ∘ Example 3 ∘ Example 7 ∘ Example 9 ∘ Comparative Example 2 xComparative Example 3 Δ

As is evident from the results shown in Table 3, it was confirmed thatthe patch of the invention is excellent in the medicine solubility and,on the other hand, patches comprising no or a little amount ofrosin-based resin as a tackifier are poor in the medicine solubility.

Test Example 3 In Vitro Medicine Skin Permeability Test

The medicine skin permeability of the transdermal patches obtained inExamples 1, 4, 5, 10 and 11 and Comparative Examples 1 and 4 wereevaluated as follows. That is, after extirpating dorsal skin of ahairless mouse (8 weeks old, female), fat on a dermis side was removedcarefully, which was set to a flow-through-cell, whose periphery of areceptor layer was circulated with water of 37° C., so that the dermisside became a receptor layer side. A patch was attached to the hornylayer side. Phosphate buffer, pH 7.4, was supplied to the receptorlayer, and sampling was carried out at a speed of 1 ml/hour every 4hours up to 24 hours. As regarding respective solutions obtained atrespective times, the flow volume was measured precisely, the medicineconcentration was measured by high performance liquid chromatography,permeability rate for 4 hours was calculated, and skin permeability rateat the steady state was determined according to the following formula.The obtained results are shown in FIGS. 2 and 3.Skin permeability rate(μg/cm ² /hr)=[Sample concentration(μg/ml)×Flowvolume(ml)]/preparation−applied area(cm ²)×4 hr

As is evident from the results shown in FIG. 2, it was confirmed thatthe patch of the invention is excellent in the medicine releasabilityand, on the other hand, patches comprising no or a little amount ofpetroleum resin as a tackifier are poor in the medicine releasability.

Further, as is evident from the results shown in FIG. 3, it wasconfirmed that use of the combination of oleyl alcohol and L-menthol(Example 10) or oleic acid and L-menthol (Example 11) especiallyimproves skin permeability of the medicine.

Test Example 4 Medicine Stability Test

The medicine stability of transdermal patches obtained in Examples 12-17was evaluated as follows. That is, the patches were preserved for 2months, 3 months or 6 months at 40° C. or for 2 months at 50° C., thenremained amount of the medicine (diclofenac) in the patches afterpreservation was measured by liquid chromatography to calculate themedicine remaining ratio (%). The measurement was repeated three times,and the average of the obtained results is shown in Table 4. TABLE 4 40°C. for 2 40° C. for 3 40° C. for 6 50° C. for 2 months months monthsmonths Ex. 12 94.0 93.2 88.1 89.3 Ex. 13 95.2 94.7 90.2 90.2 Ex. 14 96.195.3 90.3 90.5 Ex. 15 99.2 98.5 97.5 97.3 Ex. 16 98.9 98.8 98.2 98.0 Ex.17 99.0 99.0 98.2 98.1

As is evident from the results shown in Table 4, it was confirmed thatalong with increase of the average molecular weight of polyethyleneglycol, the reduction of medicine content is sufficiently suppressed.

Industrial Applicability

As described above, according to the invention, even when a medicinegenerally having difficulty in satisfying both of solubility andreleasability such as diclofenac or a salt thereof is used as themedicine, it becomes possible to obtain a transdermal patch achievingboth of sufficient solubility of the medicament and sufficientreleasability of the medicine with a good balance in a high level and,in addition, having an excellent temporal stability of the adhesiveforce.

1. A transdermal patch comprising a backing and an adhesive layerlaminated on the backing, wherein the adhesive layer comprises arosin-based resin and petroleum resin as a tackifier, the totalcompounding amount of the rosin-based resin and the petroleum resin isin a range of 15% by mass to 50% by mass, and compounding amount of thepetroleum resin is ⅓ times by mass to 4 times by mass as that of therosin-based resin.
 2. The transdermal patch according to claim 1,wherein the rosin-based resin is hydrogenated rosin ester.
 3. Thetransdermal patch according to claim 1, wherein the petroleum resin isone ore more resin selected from the group consisting of alicyclicpetroleum resin and hydrogenated alicyclic petroleum resin.
 4. Thetransdermal patch according to claim 1, wherein the adhesive layercomprises one or more selected from the group consisting of diclofenacand a pharmaceutically acceptable salt thereof as a medicament.
 5. Thetransdermal patch according to claim 1, wherein the adhesive layerfurther comprises L-menthol.
 6. The transdermal patch according to anyof claims 1-5, wherein the adhesive layer further comprises polyethyleneglycol.
 7. The transdermal patch according to claim 6, wherein theaverage molecular weight of the polyethylene glycol is in a range of200-20,000.